Materials Science and Chemistry

Biography

Biography: Bożena Tyliszczak

Abstract

Statement of the Problem: Along with the constantly observed civilization development, the medical conditions known also as the 21st century diseases are becoming a growing problem. Among these conditions, the skeletal system diseases constitute particularly significant aspect. Thus it is very important to perform investigations on the development of new, innovative bioactive biomaterials which may support bone defect treatment and favor bone tissue regeneration. Methodology & Theoretical Orientation: The main base of the developed biomaterial is a polymer matrix showing excellent mechanical properties giving at the same time appropriate elasticity. As a bioactive component, hydroxyapatite has been used to provide adequate osteointegration of the final material. Moreover, a bovine collagen has also been used. This protein was selected due to its high biological significance and biocompatibility which, in turn, result in supporting cell adhesion and proliferation by collagen modified composite.

Findings: Based on the spectroscopic analysis performed, the occurrence of the absorption bands characteristic for applied modifying agent, i.e. collagen, has been verified. Furthermore, it was demonstrated that all analyzed composite materials were characterized by sorption capability in simulated physiological liquids. Next, during the incubation of tested composites in simulated physiological liquids, i.e. during 14-day period, any rapid changes in pH values of incubation media have not been observed. All composite materials were characterized by similar surface roughness which was a result of the presence of the ceramic phase (i.e. hydroxyapatite) in all tested materials.

Conclusion & Significance: Due to such advantages of developed polymer-ceramic composite materials modified additionally with collagen as their simple and quick synthesis, biological and physicochemical properties as well as the possibility of the preparation of their sizes and shapes depending on the applied reaction vessel it may be concluded that developed biomaterials exhibited a great application potential and should be investigated using more advanced experiments. Acknowledgements: The „Multifunctional biologically active composites for applications in bone regenerative medicine” project is carried out within the TEAM-NET programme of the Foundation for Polish Science financed by the European Union under the European Regional Development Fund.