Nana N Barbakadze
Tbilisi State Medical University, Georgia
Title: Synthesis of hydrazones of 5α-androstane series
Biography
Biography: Nana N Barbakadze
Abstract
Recently, steroidal hydrazones have been receiving extensive attention of scientists because they have shown to exhibit antibacterial, antiviral and anticancer activities. Previously synthesized by us, some 5α-steroidal hydrazones have shown high antitubercular and antiviral activities. In order to find new potential bioactive compounds, hydrazones of 5α-androstane series have been synthesized. The starting ketones, 3α-hydroxy-5α-androst-9(11)-en-17-one and 5α-androst-2-en-17-one have been obtained by multistep modification of epiandrosterone — intermediate product of transformation of tigogenin. The structures of new hydrazones have been established by IR-, NMR- and mass spectral data.
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