Synthesis of 5Î±-steroidal[17,16-d]pyrazolines | Nanuli Nadaraia | Tbilisi State Medical University, Georgia |

Materials Science and Chemistry

May 17-18, 2018

An Insight into the research aspects of Chemistry for the intuition of Materials Syntheses and Processing

Nanuli Nadaraia

Tbilisi State Medical University, Georgia

Title: Synthesis of 5Î±-steroidal[17,16-d]pyrazolines

Biography

Biography: Nanuli Nadaraia

Abstract

Among the synthetic biologically active steroids pyrazolines have important place. Interest toward of these compounds is determined by their theoretical and practical meaning. Many steroidal pyrazolines have showed high anti-inflammatory, antitumor, antimicrobial and antiandrogen activities. 3β-Hydroxy-5α-pregn-16-en-20-one and its modified product - 3α-hydroxy-5α-pregna-9(11),16-dien-20-one have been synthesized from aglicon - tigogenin, isolated from plant Yucca gloriosa L. introduced in Georgia. By acid-catalyzed condensation of this α-enones with several hydrazines (phenyl-, p-chloro-, p-bromo-, p-methyl- and p-phenylphenylhydrazine) cyclocondensation products - 3β-hydroxy-1¢-aryl-3¢-methyl-5α-androstano[17,16-d]pyrazolines and 3α-hydroxy-1¢-aryl-3¢-methyl-5α-androst-9(11)-eno[17,16-d]pyrazolines have been synthesized and their biological activities have been studied.