Nader Noroozi Pesyan
Urmia University, Iran
Title: New recent advances in penta-substituted cyclopropans
Biography
Biography: Nader Noroozi Pesyan
Abstract
The cyclopropyl group is an important structure in many herbal compounds, displaying antifungal, antibacterial, antiviral and some enzyme inhibition activities. For example, bicifadine and its analogs. The first synthesis of 1,1,2,2,3-penta substituted cyclopropane was described by Mariella et al. In this research, we introduced a new method for synthesis of penta-substituted cyclopropans using ethyl cyanoacetate, malononitrile and meldrum’s acid in the presence of cyanogen bromide (BrCN) and an aldehyde under alkali condition. The obtained penta-substituted cyclopropans are useful compounds in medicinal chemistry, organic synthesis and supramolecular chemistry.